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Published on: March 6, 2018
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Clinical Features and Body Composition in Men with Hormone-Sensitive Metastatic Prostate Cancer: A Pilot Study
Patricia M Sheean1, Paula O'Connor1, Cara Joyce2
1Loyola University Chicago, 2160 South First Avenue, Cuneo 439, Maywood, Chicago, IL 60153, USA.
Prostate Cancer
|June 13, 2022
Summary
Body composition, specifically myosteatosis, is linked to poorer survival in men with metastatic prostate cancer (MPC). Black men showed increased adipose tissue gain, suggesting further research into body composition
Area of Science:
- Oncology
- Radiology
- Body Composition Analysis
Background:
- Black men with metastatic prostate cancer (MPC) generally experience better clinical outcomes than non-Black men.
- Body composition variations may explain these racial disparities in treatment outcomes.
- Preliminary data are needed to investigate the role of body composition in MPC.
Purpose of the Study:
- To explore the relationship between body composition, including adipose tissue and skeletal muscle, and clinical outcomes in men with metastatic prostate cancer (MPC).
- To investigate racial differences in body composition and their association with survival in MPC patients.
Main Methods:
- Retrospective cohort study of 74 men with MPC over 4 years.
- Computed tomography (CT) scans used to quantify adipose tissue and skeletal muscle (sarcopenia, myosteatosis).
- Time to event analyses (hazard ratios) were performed, stratified by race.
Main Results:
- 49% of men had sarcopenia, 49% had myosteatosis, and 29% had both.
- Myosteatosis at diagnosis was associated with decreased overall survival (HR: 2.34, p=0.09).
- Black men showed a greater propensity for subcutaneous adipose tissue gain (p=0.01).
Conclusions:
- Myosteatosis may negatively impact overall survival in men with MPC.
- Racial differences in body composition, particularly adipose tissue accumulation, warrant further investigation.
- Larger, powered studies with diverse populations are needed to confirm these findings.
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