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Related Experiment Videos

Appetitive learning by old mice.

J M Warren

    Experimental Aging Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Older mice show learning deficits that depend on the specific task and mouse strain. Appetitive learning methods are not suitable for studying aging mice due to high mortality rates.

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    Area of Science:

    • Neuroscience
    • Gerontology
    • Animal Behavior

    Background:

    • Aging is associated with cognitive decline, but the specific learning impairments and their suitability for research models require further investigation.
    • Understanding age-related learning changes in different mouse strains is crucial for developing effective research methodologies.

    Purpose of the Study:

    • To identify learning tasks suitable for studying cognitive aging in mice.
    • To compare the learning abilities of aged C57BL/6J (B6) and DBA/2J (D2) mice across various tasks.
    • To assess the impact of age and strain on learning performance.

    Main Methods:

    • Groups of young and old B6 and D2 mice (100-700 days old) were trained on seven appetitive learning tasks.
    • Performance was evaluated across tasks including discrimination reversal, complex mazes, spatial discrimination, visual discrimination, latent learning, and food-seeking.

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    Main Results:

    • Both old B6 and D2 mice were impaired in discrimination reversal and complex maze tasks.
    • Age did not affect performance on a simple spatial discrimination task.
    • Strain-specific deficits were observed: old B6 mice were impaired in visual discrimination, while old D2 mice showed deficits in a food-seeking task.
    • Latent learning performance differed by strain and age, with old B6 mice outperforming younger ones, and the reverse for D2 mice.
    • Excessive mortality occurred in the oldest groups during deprivation, deeming appetitive learning unsuitable for this age group.

    Conclusions:

    • Learning deficits in aging mice are both task- and strain-specific.
    • Appetitive learning paradigms are contraindicated for studying learning in very old mice due to high mortality.
    • Further research is needed to identify appropriate methods for assessing cognitive function in aging rodent models.