Dandy-Walker malformation and intermittent explosive disorder: A case report.

Area of Science:

• Neuroscience
• Psychiatry
• Genetics

Background:

• Dandy-Walker malformation (DWM) is a congenital brain defect.
• It is associated with various neurological and psychiatric conditions.
• Behavioral symptoms like psychosis and aggression are sometimes observed in DWM patients.

Observation:

• A case report of an 18-year-old male with Dandy-Walker malformation is presented.
• The patient exhibited anger outbursts, irritable mood, and violent behavior, consistent with intermittent explosive disorder.
• MRI confirmed typical Dandy-Walker malformation alterations, alongside mild intellectual disabilities and epilepsy.

Findings:

• The patient received a combination treatment of sodium valproate and risperidone.
• Significant reduction in violent behavior was observed during follow-ups at 3 months, 6 months, and 1 year.
• This suggests a potential therapeutic response for DWM-associated behavioral disturbances.

Implications:

• The findings suggest a possible link between Dandy-Walker malformation and intermittent explosive disorder.
• Understanding this association may aid in recognizing DWM as a potential cause of psychiatric comorbidities.
• Further research into the neurobiological underpinnings connecting DWM and behavioral disorders is warranted.