Related Experiment Video
Updated: Sep 8, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.0K
Treating psoriasis in the elderly: biologics and small molecules
Matteo Megna1, Luca Potestio1, Gabriella Fabbrocini1
1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Expert Opinion on Biological Therapy
|June 13, 2022
Summary
Biologics and small molecules offer effective psoriasis treatment for elderly patients, even with comorbidities. These advanced therapies provide a tailored approach for long-term remission and improved quality of life.
Area of Science:
- Dermatology
- Geriatrics
- Pharmacology
Background:
- Psoriasis prevalence is increasing in the elderly population.
- 15% of elderly psoriasis patients have moderate-to-severe disease requiring systemic treatment.
- Conventional systemic agents have limitations in the elderly due to contraindications and drug interactions.
Purpose of the Study:
- To review the efficacy and safety of biologics and small molecules for psoriasis in the elderly.
- To address the lack of specific guidelines for geriatric psoriasis treatment.
- To highlight the potential of targeted therapies in this population.
Main Methods:
- A comprehensive literature search was conducted for English studies on biologics and/or small molecules in elderly psoriasis patients.
- The search included trials, real-life studies, case series, and reviews up to January 17, 2022.
Main Results:
- Biologics and small molecules demonstrate efficacy and safety in elderly patients with psoriasis.
- Real-world data show comparable outcomes to younger adults.
- Tailored management considering comorbidities and frailties is crucial.
Conclusions:
- Targeted therapies like biologics and small molecules are valuable options for moderate-to-severe psoriasis in the elderly.
- These treatments can achieve long-term remission and improve quality of life.
- Personalized treatment strategies are essential for geriatric psoriasis patients.
More Related Videos
Related Concept Videos
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
230
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
230
01:29Inflammatory Bowel Disease IV: Pharmacological Management
177
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
177
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
264
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
264
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
200
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
200
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
01:26COPD: Management Using Bronchodilators and Corticosteroids
300
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
300