Symbiotic microorganisms: prospects for treating atopic dermatitis

Area of Science:

• Microbiology
• Dermatology
• Immunology

Background:

• Atopic dermatitis (AD) is a prevalent, chronic inflammatory skin condition with complex pathogenesis.
• Factors contributing to AD include genetics, immune responses, environmental influences, and impaired skin barrier function.
• The role of symbiotic microorganisms in the gut and on the skin is increasingly recognized in AD occurrence.

Purpose of the Study:

• To review the metabolism and distribution of intestinal and skin flora.
• To examine the relationship between gut and skin microbiota and AD.
• To summarize current applications and future prospects of microbiota-targeted therapies for AD.

Main Methods:

• Literature search of the PubMed database (1949-2020).
• Bibliometric analysis of publications on atopic dermatitis and symbiotic microorganisms.
• Review of existing studies on microbial contributions to AD.

Main Results:

• Skin bacteria can exacerbate AD through virulence factors.
• Intestinal flora metabolism influences AD development via the circulatory system.
• Evidence supports the potential of regulating gut and skin flora for AD treatment and prevention.

Conclusions:

• Microbiota in the gut and on the skin play a significant role in atopic dermatitis.
• Targeting and regulating these microbial communities presents a viable strategy for AD management.
• Further research into human microbiota systems holds promise for advancing AD treatment.