Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

115.6K
Overview
115.6K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

311
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
311
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.1K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.1K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

7.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
7.2K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

7.1K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
7.1K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell RNA-seq of in vitro-cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency.

Journal of leukocyte biology·2026
Same author

Distinct mutations in the autoimmune regulator gene differentially affect transcriptional and functional properties of medullary thymic epithelial cells.

Human molecular genetics·2026
Same author

PTEN inhibition induces neuronal differentiation and neuritogenesis in SH-SY5Y cells via AKT signaling pathway.

Journal of Alzheimer's disease : JAD·2025
Same author

Novel donepezil-tacrine hybrid (TAHB3) induces neurodifferentiation, neuroprotective effects, and activates the PI3K/AKT pathway on PC12 cells.

Journal of Alzheimer's disease reports·2025
Same author

Repopulation of a 3D simulated periapical lesion cavity with dental pulp stem cell spheroids with triggered osteoblastic differentiation.

Brazilian dental journal·2024
Same author

Preface: Regulatory T Cells in Immune Homeostasis.

Critical reviews in immunology·2023
Same journal

Leveraging Type I Interferons: Exploring Pathogenesis and Therapeutic Strategies in Autoimmune Diseases.

Critical reviews in immunology·2026
Same journal

SLC2A1-Dependent Ketone Metabolism Regulates Tumor Progression and Immunotherapy Efficacy in Lung Adenocarcinoma.

Critical reviews in immunology·2026
Same journal

Knockdown of IGF2BP2 Inhibits THBS1 in Regulating the Progression of Oral Squamous Cell Carcinoma: An Integrative Analysis.

Critical reviews in immunology·2026
Same journal

Plasmodium Phosphatidylinositol 4-Kinase Beta (PI4Kβ): An Emerging Target at the Interface of Parasite Biology and Host Immunity.

Critical reviews in immunology·2026
Same journal

Fusion Gene EPHB4-MET Driven by HOXA9 and Exerted Oncogenic Activity in Non-Small Cell Lung Cancer.

Critical reviews in immunology·2026
Same journal

Secreted Phosphoprotein 1 Represents a Therapeutic Target that Promotes the Progression of Ovarian Cancer by Driving M2 Macrophage Infiltration.

Critical reviews in immunology·2026
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

29.3K

Preface Special Issue: Microbiome-Immune System Interactions.

Geraldo Aleixo Passos1, Vipin Kumar Chaturvedi2

  • 1Molecular Immunogenetics Group, University of São Paulo, Ribeirão Preto Campus, SP, Brazil.

Critical Reviews in Immunology
|June 13, 2022
PubMed
Summary
This summary is machine-generated.

The human microbiome, including gut bacteria and viruses, influences immune responses, disease susceptibility, and treatment outcomes. This issue explores the microbiome

More Related Videos

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.5K
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

8.9K

Related Experiment Videos

Last Updated: Sep 8, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

29.3K
An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.5K
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

8.9K

Area of Science:

  • Microbiology
  • Immunology
  • Oncology

Background:

  • The human microbiome plays a crucial role in maintaining body homeostasis and immune responses.
  • Microbial composition is increasingly linked to disease susceptibility, including cancer, autoimmune disorders, and behavioral conditions.
  • The gut microbiome, comprising viruses, bacteria, and yeast, significantly impacts health and therapeutic responses.

Purpose of the Study:

  • To explore the intricate relationship between the human microbiome and specific disease classes.
  • To focus on the processes connecting the microbiome to immunodeficiency, autoimmunity, and cancer.
  • To review recent advancements in understanding these connections.

Main Methods:

  • This Special Issue compiles review articles.
  • Articles cover recent progress in selective immunoglobulin A (IgA) deficiency.
  • Reviews address Sjörgren's syndrome and breast cancer in relation to the microbiome.

Main Results:

  • The composition of the microbiome, including pathogenic and commensal microbes, is strongly associated with disease resistance or susceptibility.
  • Specific microbial communities influence the development and progression of immunodeficiency, autoimmune diseases, and cancer.
  • Recent research highlights the role of selective immunoglobulin A (IgA) deficiency, Sjörgren's syndrome, and breast cancer in microbiome-disease associations.

Conclusions:

  • The human microbiome is a critical factor in health and disease.
  • Understanding microbiome-host interactions is vital for developing novel therapeutic strategies for immune-related diseases and cancer.
  • Further research into the microbiome's role in immunodeficiency, autoimmunity, and cancer is warranted.