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Low dose omeprazole effects on gastric acid secretion in normal man
Gastroenterologie Clinique Et Biologique
|February 1, 1987
Summary
Low-dose omeprazole (10 mg/d) effectively reduces gastric acid secretion for over 24 hours without significantly impacting gastrin levels. This finding suggests omeprazole 10 mg daily may be sufficient for treating duodenal ulcers, especially for long-term therapy.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- The pharmacological effects of low-dose omeprazole (Om) are not well-established.
- Investigating the efficacy of 10 mg/d omeprazole (Om10) compared to 20 mg/d (Om20) is crucial for optimizing treatment strategies.
Purpose of the Study:
- To evaluate the effects of a 7-day treatment with low-dose omeprazole (10 mg/d) on gastric acid secretion and serum gastrin levels.
- To compare these effects with a standard antisecretory dose (20 mg/d).
Main Methods:
- A randomized, double-blind, placebo-controlled study involving 12 healthy volunteers.
- Participants received placebo, Om10, or Om20 daily for 7-day periods.
- Gastric acid secretion was measured via 24-hour pH monitoring and basal, sham-feeding, and pentagastrin-stimulated acid output (BAO, SAO, PAO).
Main Results:
- Both Om10 and Om20 significantly inhibited gastric acid concentrations in a dose-dependent and prolonged manner, including nocturnal secretion.
- Om10 reduced BAO, SAO, and PAO by 52%, 35%, and 28% respectively, while Om20 reduced them by 60%, 58%, and 50%.
- Fasting serum gastrin levels increased significantly with Om20 but not with Om10.
Conclusions:
- Treatment with 10 mg/d omeprazole demonstrates a consistent and long-lasting inhibitory action on gastric acidity.
- Omeprazole 10 mg daily may be sufficient for effectively inhibiting gastric acidity in certain duodenal ulcer patients, particularly for long-term treatment.
- Low-dose omeprazole (10 mg/d) does not significantly affect serum gastrin levels, unlike the 20 mg/d dose.