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Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic
Hao Wu1,2, Tingzi Hu1, Meihua Xu3
1School of Medicine, University of Missouri, Columbia, Missouri, USA.
Insights
This systematic review investigates if inflammatory bowel disease (IBD) patients face a higher risk of cardiovascular disease (CVD). We analyze observational studies on endothelial function, arterial stiffness, and carotid intima-media thickness to assess the CVD burden in IBD.
Area of Science:
- Cardiovascular Medicine
- Gastroenterology
- Systematic Review and Meta-Analysis
Background:
- Inflammatory Bowel Disease (IBD) is associated with chronic inflammation.
- Emerging evidence suggests a potential link between IBD and increased cardiovascular disease (CVD) risk.
- Understanding this association is crucial for comprehensive patient management.
Purpose of the Study:
- To systematically review and analyze existing observational studies.
- To determine if patients with IBD exhibit an increased burden of cardiovascular disease (CVD).
- To evaluate markers of endothelial function, arterial stiffness, and carotid intima-media thickness in IBD patients.
Main Methods:
- Systematic review of observational studies adhering to PRISMA guidelines.
- Quality assessment of included studies using the Newcastle-Ottawa Scale.
- Potential meta-analysis with fixed and random effects models; heterogeneity assessed using I² tests.
- Subgroup analyses based on disease category, gender, and disease activity.
Main Results:
- Data synthesis will quantify the association between IBD and CVD risk markers.
- Meta-analysis will provide pooled effect sizes if data permit.
- Subgroup analyses will explore potential moderating factors.
Conclusions:
- The findings will elucidate the relationship between IBD and cardiovascular health.
- Results will inform clinical practice regarding CVD risk assessment in IBD patients.
- Dissemination through peer-reviewed publications and conferences is planned.
Introduction:
Patients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden.
Methods And Analysis:
We will conduct a systematic review of all observational studies that examine endothelial function, arterial stiffness and carotid intima-media thickness in patients with IBD. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and study quality will be assessed using the Newcastle-Ottawa Scale. If sufficient data are available, a meta-analysis will be conducted. The overall effect sizes will be estimated using both fixed effects models and random effects models. Statistical heterogeneity will be calculated using Higgin's (I2) tests. Subgroup analyses, conditional number of studies retrieved and their sample size, will be stratified according to participant disease category or gender or disease activity.
Ethics And Dissemination:
Formal ethics approval is not required as individual data will not be collected. The results will be disseminated through peer-reviewed publications, conference presentations and scientific news releases.
Prospero Registration Number:
CRD42021274093.
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