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Related Experiment Video

Updated: Sep 8, 2025

Control of Eating Behavior Using a Novel Feedback System
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Aberrant impulse control circuitry in obesity.

Daniel A N Barbosa1,2, Fiene Marie Kuijper1, Jeffrey Duda3

  • 1Department of Neurosurgery, Pennsylvania Hospital, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Molecular Psychiatry
|June 13, 2022
PubMed
Summary
This summary is machine-generated.

Aberrations in the ventromedial prefrontal cortex (vmPFC) to nucleus accumbens (NAc) shell circuit are linked to obesity and binge eating. Deep brain stimulation of this circuit reduced uncontrolled eating and BMI in a patient.

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Medical Imaging

Background:

  • The ventromedial prefrontal cortex (vmPFC) to nucleus accumbens (NAc) circuit is involved in impulsive reward-seeking, which is linked to obesity and binge eating.
  • It is unclear if this circuit is disrupted in individuals with obesity who exhibit impulsive eating behaviors.

Purpose of the Study:

  • To investigate the relationship between the vmPFC-NAc shell circuit and obesity in women with binge eating behaviors.
  • To explore the potential of modulating this circuit for treating binge eating and obesity.

Main Methods:

  • Analysis of publicly available neuroimaging data to identify vmPFC-NAc structural convergence.
  • Multimodal analysis of clinical and imaging data in female participants with binge eating.
  • First-in-human deep brain stimulation (DBS) of the NAc shell in an obese, binge-prone individual.

Main Results:

  • vmPFC-NAc shell resting-state and structural connectivity, as well as vmPFC thickness, were inversely correlated with BMI.
  • Obese, binge-prone participants showed reduced vmPFC-NAc shell connectivity and vmPFC thickness.
  • NAc shell DBS in one participant led to reduced binge eating episodes and BMI.

Conclusions:

  • The vmPFC-NAc shell circuit is perturbed in obesity associated with binge eating.
  • Modulating the vmPFC-NAc shell circuit shows promise for restoring eating behavior control in obesity.