Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Gao et al. <i>Camellia japonica</i> Flower Extract and the Active Constituent Hyperoside Repair DNA Damage Through FUNDC1-Mediated Mitophagy Pathway for Skin Anti-Aging. <i>Antioxidants</i> 2025, <i>14</i>, 968.

Antioxidants (Basel, Switzerland)·2026
Same author

<i>Camellia japonica</i> Flower Extract and the Active Constituent Hyperoside Repair DNA Damage Through FUNDC1-Mediated Mitophagy Pathway for Skin Anti-Aging.

Antioxidants (Basel, Switzerland)·2025
Same author

Discovery of Arene Ruthenium(II) Complexes as Potential VEGF Inhibitors for Glioblastoma Metastasis Suppression.

Journal of medicinal chemistry·2024
Same author

Uridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer.

JACS Au·2024
Same author

Preparation, Characterization, and Antioxidant Activities of Extracts from <i>Amygdalus persica</i> L. Flowers.

Molecules (Basel, Switzerland)·2024
Same author

Novel Chiral Ru(II) Complexes as Potential c-myc G-quadruplex DNA Stabilizers Inducing DNA Damage to Suppress Triple-Negative Breast Cancer Progression.

International journal of molecular sciences·2023

Related Experiment Video

Updated: Sep 8, 2025

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

14.9K

Fast detection, a precise and sensitive diagnostic agent for breast cancer.

Qiong Wu1,2, Chanling Yuan1,2, Ningzhi Liu1,2

  • 1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.

Journal of Experimental & Clinical Cancer Research : CR
|June 13, 2022
PubMed
Summary

A novel nanoprobe, AS1411@RuPEP, effectively targets and images breast cancer cells by recognizing nucleolin (NCL). This tool aids in distinguishing tumor cells and evaluating breast cancer pathology.

Keywords:
AS1411Breast cancerNCLTumor-targeting imaging

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.1K

Related Experiment Videos

Last Updated: Sep 8, 2025

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

14.9K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

22.6K
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.1K

Area of Science:

  • Nanotechnology
  • Biomedical Imaging
  • Oncology

Background:

  • Effective breast cancer diagnostic agents are crucial for treatment planning and evaluation.
  • A novel tumor-targeting nanoprobe, AS1411@RuPEP, utilizes liquid-liquid phase separation for phosphorescence imaging of breast cancer cells.

Purpose of the Study:

  • To develop and characterize a nanoprobe for enhanced breast cancer detection and imaging.
  • To evaluate the in vitro and in vivo targeting and imaging capabilities of the AS1411@RuPEP nanoprobe.

Main Methods:

  • Designed and constructed the AS1411@RuPEP nanoprobe.
  • Characterized physicochemical properties using TEM, AFM, and EDS.
  • Evaluated diagnostic capacity via cell co-culture, xenograft tracking, and human tissue analysis.

Main Results:

  • The nanoprobe demonstrated excellent in vitro and in vivo tumor-targeting imaging by recognizing over-expressed nucleolin (NCL) on breast cancer cells.
  • Nanoprobe enrichment in tumor cells is linked to ATP-dependent NCL transport, mediated by the AS1411 component.
  • Histological analysis showed clear differentiation between cancerous and non-cancerous human breast tissue.

Conclusions:

  • The study presents a potent nanoprobe for highlighting and distinguishing tumor cells in vivo.
  • This tool facilitates tumor grading and staging in pathological sections of breast cancer patients.
  • The findings offer an effective method for breast cancer diagnostic imaging through targeted NCL recognition.