Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
The Parathyroid Glands00:59

The Parathyroid Glands

2.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Phenotypic and transcriptomic characterization of two newly described Mycobacterium species within the <i>Mycobacterium gordonae</i> complex.

Frontiers in microbiology·2026
Same author

Fructus xanthii Extract Alleviates Osteoarthritis by Preserving Cartilage Integrity.

Journal of visualized experiments : JoVE·2026
Same author

Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16.

Journal for immunotherapy of cancer·2026
Same author

Biomarkers for differentiating diabetic periodontitis from chronic periodontitis: a systematic review and meta-analysis.

Frontiers in immunology·2026
Same author

Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase.

Neural regeneration research·2026
Same author

Legacy-buffered groundwater nitrate limits predictability from short-term hydroclimatic windows across intensive wheat-maize croplands.

Environmental research·2026
Same journal

Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

Radiology·2026
Same journal

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same journal

Erratum for: Blue Rubber Bleb Nevus Syndrome.

Radiology·2026
Same journal

Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

Radiology·2026
Same journal

To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

Radiology·2026
Same journal

The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

Radiology·2026
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
04:23

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

2.0K

A Practical CEUS Thyroid Reporting System for Thyroid Nodules.

Jingliang Ruan1, Xiaolin Xu1, Yan Cai1

  • 1From the Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (J.R., X.X., M.L., W.Z., R.L., P.L., B.O., B.L.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation (J.R., X.X., M.L., W.Z., R.L., B.O., B.L.), and Department of Otolaryngology, Head and Neck Surgery (P.L.), No. 33 Yingfeng Rd, Guangzhou 510289, China; Department of Ultrasound, Central People's Hospital of Zhanjiang, Zhanjiang, China (Y.C., Y.X.); and Department of Ultrasound, Affiliated Huadu Hospital of Southern Medical University, Guangzhou 510810, China (H.Z., Q.Y.).

Radiology
|June 14, 2022
PubMed
Summary
This summary is machine-generated.

A new contrast-enhanced ultrasound (CEUS) system improves thyroid nodule risk assessment, reducing unnecessary biopsies. This CEUS TI-RADS offers higher accuracy in stratifying malignancy risk for better patient management.

More Related Videos

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

730
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

25.7K

Related Experiment Videos

Last Updated: Sep 8, 2025

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
04:23

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

2.0K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

730
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

25.7K

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • The diagnostic role of contrast-enhanced ultrasound (CEUS) in thyroid nodule evaluation remains underexplored.
  • Reducing unnecessary fine-needle aspiration (FNA) biopsies is crucial for patient care and healthcare efficiency.

Purpose of the Study:

  • To develop and validate a novel Thyroid Imaging Reporting and Data System (TI-RADS) incorporating both nonenhanced ultrasound and CEUS features.
  • To enhance the stratification of malignancy risk in thyroid nodules using this integrated imaging approach.

Main Methods:

  • A retrospective analysis of 801 thyroid nodules from 756 patients who underwent nonenhanced US, CEUS, and FNA biopsy.
  • Logistic regression analysis identified independent predictive features from qualitative US and CEUS findings to construct the CEUS TI-RADS.
  • Internal cross-validation and two independent external validation sets were used to assess the system's performance.

Main Results:

  • The developed CEUS TI-RADS demonstrated a superior area under the receiver operating characteristic curve (0.93) compared to existing systems.
  • It achieved a high biopsy yield for malignancy (66%) while significantly reducing the unnecessary biopsy rate (34%).
  • External validation confirmed robust performance with areas under the curve of 0.89 and 0.90, and malignancy yields of 61% and 57% respectively.

Conclusions:

  • A new CEUS-based TI-RADS effectively stratifies thyroid nodule malignancy risk by integrating nonenhanced US and CEUS qualitative features.
  • This system shows promise in improving diagnostic accuracy and reducing the need for invasive procedures like FNA biopsies.
  • The CEUS TI-RADS represents a valuable advancement in the noninvasive evaluation of thyroid nodules.