Related Experiment Video
Updated: Sep 8, 2025
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
3.8K
Preoperative inflammatory markers for predicting parathyroid carcinoma
Keiko Ohkuwa1, Kiminori Sugino1, Ryohei Katoh2
1Department of Surgery, Ito Hospital, Tokyo, Japan.
Endocrine Connections
|June 14, 2022
Summary
Preoperative inflammatory markers can help predict parathyroid carcinoma. A decreased lymphocyte-to-monocyte ratio (LMR) and larger tumor size significantly indicate cancer risk.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Parathyroid carcinoma is a rare but aggressive endocrine malignancy.
- Diagnosis is often delayed due to reliance on postoperative histopathology.
- Preoperative diagnostic tools are crucial for timely intervention.
Purpose of the Study:
- To investigate the utility of preoperative inflammatory markers in predicting parathyroid carcinoma.
- To identify potential predictors for differentiating parathyroid carcinoma from parathyroid adenoma.
- To assess the role of lymphocyte-to-monocyte ratio (LMR) and tumor size in preoperative diagnosis.
Main Methods:
- Retrospective analysis of 36 parathyroid carcinoma and 50 parathyroid adenoma cases.
- Comparison of preoperative clinical characteristics and inflammatory markers, including LMR.
- Multivariate analysis and receiver operating characteristic (ROC) analysis to identify independent predictors.
Main Results:
- Parathyroid carcinoma cases showed significantly higher intact-parathyroid hormone, serum calcium, and tumor diameter.
- A significant decrease in LMR was observed in parathyroid carcinoma.
- LMR (cutoff ≤ 4.85) and tumor diameter (cutoff ≥ 28.0 mm) were independent predictors of parathyroid cancer.
Conclusions:
- Preoperative LMR and tumor diameter are valuable indicators for predicting parathyroid carcinoma.
- Combining LMR and tumor diameter enhances the accuracy of preoperative cancer prediction.
- These findings may aid in improving the preoperative diagnosis of parathyroid malignancies.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
00:59The Parathyroid Glands
2.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.5K