Related Experiment Video

Updated: Sep 8, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms

Yirao Zhang1, Yang Wang1, Hao Ji2

  • 1Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.

Journal of Experimental & Clinical Cancer Research : CR
|June 14, 2022
PubMed

Insights

The Hippo pathway, regulated by YAP/TAZ proteins, controls cell growth. This review details how noncoding RNAs (ncRNAs) interact with YAP/TAZ, impacting cancer progression.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Hippo signaling pathway regulates organ size and cell regeneration.
  • Dysregulation of this pathway, particularly YAP/TAZ effectors, drives uncontrolled cell proliferation and cancer.
  • Noncoding RNAs (ncRNAs) are increasingly recognized for their roles in cancer development.

Purpose of the Study:

  • To review the intricate interactions between YAP/TAZ signaling and various ncRNAs (miRNAs, lncRNAs, circRNAs).
  • To elucidate the biological functions of these interactions in cancer progression.
  • To describe the complex feedback loops governing YAP/TAZ and ncRNA networks.

Main Methods:

  • Literature review of studies investigating YAP/TAZ signaling and ncRNAs in cancer.
  • Analysis of mechanisms by which ncRNAs regulate YAP/TAZ.
  • Examination of how YAP/TAZ influence ncRNA expression.

Main Results:

  • ncRNAs directly and indirectly modulate YAP/TAZ activity.
  • YAP/TAZ signaling reciprocally regulates the expression of ncRNAs.
  • These interactions significantly impact cancer initiation, growth, and progression.

Conclusions:

  • The interplay between YAP/TAZ and ncRNAs forms complex regulatory networks crucial in cancer.
  • Targeting these interactions presents potential therapeutic strategies for cancer treatment.
Keywords:
CarcinogenesisTAZYAPncRNA

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