Small-Fiber Neuropathy Possibly Associated with COVID-19

Area of Science:

• Neurology
• Infectious Diseases
• Peripheral Nervous System Disorders

Background:

• COVID-19 is known to cause neurological complications affecting both central and peripheral nervous systems.
• Research on COVID-19's impact on the peripheral nervous system (PNS) remains limited.
• Diagnosing PNS complications can be challenging due to limited access to specialized evaluations.

Observation:

• This report details two cases presenting with symptoms suggestive of small-fiber neuropathy (SFN).
• These cases occurred in the context of or following COVID-19 infection.
• Paresthesia (tingling or numbness) was a key symptom observed in these patients.

Findings:

• The presented cases suggest a potential association between COVID-19 infection and the development of small-fiber neuropathy (SFN).
• The findings underscore the need for increased clinical awareness regarding this possible complication.
• Diagnostic methods like nerve conduction studies and skin biopsies may be crucial for confirming SFN in post-COVID-19 patients.

Implications:

• Increased consideration of SFN in patients experiencing paresthesia during or after COVID-19 infection is recommended.
• Further research is warranted to elucidate the neuropathological mechanisms underlying COVID-19-related SFN.
• Investigating the efficacy of immunomodulatory treatments, such as intravenous immunoglobulin, for COVID-19-associated SFN is crucial.