Related Experiment Video

Updated: Sep 8, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

729

Retraction

    Journal of Cellular Biochemistry
    |June 15, 2022
    PubMed

    Insights

    This retracted study investigated miR-200c's role in colorectal cancer, focusing on cancer stem cells and epithelial-mesenchymal transition. Invalid experimental data led to the article's retraction.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Context:

    • Colorectal cancer (CRC) is a significant global health concern.
    • Cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) are critical drivers of CRC progression and metastasis.
    • MicroRNAs (miRNAs) are emerging as key regulators in cancer development.

    Purpose:

    • To investigate the role of miR-200c as a tumor suppressor in colorectal cancer.
    • To examine the modulation of cancer stem cell markers by miR-200c.
    • To assess the impact of miR-200c on epithelial-mesenchymal transition in CRC.

    Summary:

    • The study focused on miR-200c's potential tumor-suppressive functions in colorectal cancer.
    • It aimed to elucidate how miR-200c affects the expression of cancer stem cell markers.
    • The research also explored miR-200c's influence on the epithelial-mesenchymal transition process.

    Impact:

    • The article, "miR-200c, a tumor suppressor that modulate the expression of cancer stem cells markers and epithelial-mesenchymal transition in colorectal cancer," has been retracted.
    • Retraction was based on the discovery of duplicated image elements in the experimental data, rendering the conclusions invalid.
    • This retraction highlights the importance of rigorous data validation in scientific publishing.

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