Related Experiment Video
Updated: Sep 8, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Genetic and epigenetic nutritional interactions influencing obesity risk and adiposity outcomes
Omar Ramos-Lopez1, Jose Ignacio Riezu-Boj2,3, Fermin I Milagro2,3,4
1Medicine and Psychology School, Autonomous University of Baja California, Tijuana, Baja California, Mexico.
Purpose Of Review:
This article aims to critically overview the current interplay of genetic/epigenetic factors and several nutritional aspects influencing obesity susceptibility and adiposity outcomes for obesity management and weight status monitoring.
Recent Findings:
Single nucleotide polymorphisms located in or near genes participating in energy homeostasis, fatty acid metabolism, appetite control, brain regulation, and thermogenesis have been associated with body composition measures (body weight, body mass index, waist circumference, body fat percentage, and visceral adipose tissue) depending on nutrient intakes, dietary patterns, and eating behaviors. Moreover, studies analyzing interactions between the epigenome and dietary intakes in relation to adiposity outcomes are reported. The main epigenetic mechanisms include methylation levels of promoter sequences, telomere length, and micro-ribonucleic acid expression profiles, whereas covalent histone modifications remain less studied.
Summary:
Exploring potential interactions between the genetic/epigenetic background and nutritional features is improving the current understanding of the obesity physiopathogenesis and the usefulness of translating this precision information in the clinical setting for weight gain prediction, the design of personalized nutrition therapies as well as individual responsiveness estimation to dietary advice. The analysis of further relationships between the genotype, the epigenotype and other precision markers including the gut microbiota and the metabolome is warranted.
More Related Videos
Related Concept Videos
Gene-Environment Interactions
Obesity
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Epigenetic Regulation
X-chromosome...
Regulation of Food Intake
Nature and Nurture

