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Related Experiment Video

Updated: Sep 8, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Hebbian activity-dependent plasticity in white matter.

Alberto Lazari¹, Piergiorgio Salvan¹, Michiel Cottaar¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX2 6GG, UK.

|June 15, 2022

Summary

This summary is machine-generated.

Brain plasticity extends beyond synapses to white matter. This study shows myelin plasticity in human white matter follows Hebb's rule, similar to synaptic learning principles.

Keywords:

CP: Neuroscience Hebbian plasticity action reprogramming brain plasticity brain stimulation magnetic resonance imaging myelin myelin plasticity white matter

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Last Updated: Sep 8, 2025

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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

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Area of Science:

Neuroscience
Neuroplasticity
White Matter Biology

Background:

Synaptic plasticity, governed by Hebb's rule, is crucial for learning and memory.
Recent research identified myelin plasticity in white matter, but its underlying principles remained unknown.
Understanding white matter plasticity is key to comprehending brain learning mechanisms.

Purpose of the Study:

To investigate whether white matter plasticity in humans operates under Hebb's rule.
To determine if myelin plasticity follows the same computational principles as synaptic plasticity.
To provide evidence for Hebbian mechanisms in human white matter.

Main Methods:

Two experiments involving co-stimulation of cortical areas to induce Hebbian plasticity.
Measurement of cortical excitability changes.
Assessment of myelin marker changes within stimulated white matter fiber bundles.

Main Results:

Co-stimulation induced relative increases in cortical excitability.
Associated increases in a myelin marker were observed within the stimulated fiber bundle.
Evidence suggests myelin plasticity follows Hebb's rule in humans.

Conclusions:

Hebbian plasticity is not limited to synaptic changes but extends to human white matter.
Myelin plasticity in white matter operates under Hebb's rule.
This finding broadens our understanding of the neural mechanisms underlying learning and brain adaptation.