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DEPDC1B collaborates with GABRD to regulate ESCC progression.

Yunfeng Yuan1, Wei Ping2, Ruijie Zhang2

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China.

Cancer Cell International
|June 15, 2022
PubMed
Summary
This summary is machine-generated.

DEPDC1B and GABRD collaborate to drive esophageal squamous cell carcinoma (ESCC) progression. Inhibiting this DEPDC1B-GABRD axis offers a promising therapeutic strategy for ESCC patients.

Keywords:
DEPDC1BESCCGABRDPhenotypePrognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Esophageal squamous cell carcinoma (ESCC) presents a significant global health challenge with poor patient outcomes.
  • The DEP domain-containing protein 1B (DEPDC1B) is implicated in various cancers, necessitating investigation into its role in ESCC.

Purpose of the Study:

  • To elucidate the function of DEPDC1B in ESCC pathogenesis.
  • To identify DEPDC1B as a potential therapeutic target for ESCC.

Main Methods:

  • DEPDC1B expression analysis using TCGA database and immunohistochemistry.
  • Kaplan-Meier survival analysis for DEPDC1B in ESCC patients.
  • In vitro and in vivo functional studies involving DEPDC1B knockdown via shRNA.

Main Results:

  • DEPDC1B is overexpressed in ESCC and inversely correlated with patient survival.
  • DEPDC1B inhibition suppressed ESCC cell proliferation, migration, and tumor formation, while promoting apoptosis.
  • DEPDC1B interacts with GABRD, and this interaction is crucial for ESCC progression, potentially mediated by the PI3K/AKT/mTOR pathway.

Conclusions:

  • DEPDC1B and GABRD cooperate to drive ESCC progression.
  • Targeting the DEPDC1B-GABRD signaling axis represents a potential therapeutic strategy for ESCC.