Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Systems-II01:31

Classification of Systems-II

240
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
240
BIBO stability of continuous and discrete -time systems01:24

BIBO stability of continuous and discrete -time systems

506
System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
506
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

100
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
100
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

121
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
121
State Space Representation01:27

State Space Representation

281
The frequency-domain technique, commonly used in analyzing and designing feedback control systems, is effective for linear, time-invariant systems. However, it falls short when dealing with nonlinear, time-varying, and multiple-input multiple-output systems. The time-domain or state-space approach addresses these limitations by utilizing state variables to construct simultaneous, first-order differential equations, known as state equations, for an nth-order system.
Consider an RLC circuit, a...
281
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

252
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
252

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Patients With Sepsis: Case Study.

JMIR medical informatics·2026
Same author

An AI-Based Clinical Decision Support System for Antibiotic Therapy in Sepsis (KINBIOTICS): Use Case Analysis.

JMIR human factors·2025
Same author

The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers.

Viruses·2023
Same author

Identifiability analysis for models of the translation kinetics after mRNA transfection.

Journal of mathematical biology·2022
Same author

Publisher Correction: Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the German Study Group-MPN.

Leukemia·2021
Same author

Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich.

International journal of environmental research and public health·2021
Same journal

Elastic functional Cox regression model with shape predictors.

Journal of applied statistics·2026
Same journal

An improved two-stage binary relevance method for multilabel classification.

Journal of applied statistics·2026
Same journal

Classification of multivariate functional data with an application to ADHD fMRI data.

Journal of applied statistics·2026
Same journal

Assessing the performance of longitudinal T-lymphocytes as biomarkers of immune recovery in HIV-infected children with or without TB co-infection.

Journal of applied statistics·2026
Same journal

Sparse long-only Markowitz portfolio optimization.

Journal of applied statistics·2026
Same journal

Homogeneity of multinomial populations when data are classified into a large number of groups.

Journal of applied statistics·2026
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.3K

An MCMC computational approach for a continuous time state-dependent regime switching diffusion process.

El Houcine Hibbah1, Hamid El Maroufy1, Christiane Fuchs2,3,4

  • 1Department of Applied Mathematics, Faculty of Sciences and Technics, Sultan Mouly Slimane University, Morocco.

Journal of Applied Statistics
|June 16, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a Bayesian Markov chain Monte Carlo approach for simulating complex hybrid switching diffusion (HSD) processes. This method effectively estimates latent data, regime states, and model parameters for HSD models.

Keywords:
Hybrid switching diffusion modeldata imputationhidden states computationrandom time imputationstates computation

More Related Videos

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.8K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.2K

Related Experiment Videos

Last Updated: Sep 8, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.3K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.8K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.2K

Area of Science:

  • Computational Statistics
  • Stochastic Processes
  • Bayesian Inference

Background:

  • State-dependent regime switching diffusion processes (HSD) pose simulation challenges for classical methods.
  • Real-world phenomena are observed at discrete times, necessitating data imputation for accurate diffusion process density approximation.

Purpose of the Study:

  • To develop and apply a Markov chain Monte Carlo (MCMC) Bayesian approach for estimating complex Hybrid Switching Diffusion (HSD) models.
  • To address the simulation difficulties of HSD processes by integrating Bayesian inference.

Main Methods:

  • Utilized a Markov chain Monte Carlo (MCMC) Bayesian framework for model estimation.
  • Employed a Metropolis Hastings algorithm for updating latent imputed data at random intervals.
  • Adapted a forward filtering backward smoothing algorithm for computing regime switching states.
  • Applied Gibbs sampler or Metropolis Hastings algorithm for parameter estimation after prior specification.

Main Results:

  • Successfully computed latent imputed observations within a Bayesian context.
  • Accurately determined regime switching states using an adapted forward filtering backward smoothing algorithm.
  • Estimated model parameters through conditional posterior densities using MCMC methods.

Conclusions:

  • The proposed MCMC Bayesian approach is effective for estimating and simulating Hybrid Switching Diffusion (HSD) processes.
  • Data imputation and Bayesian methods are crucial for handling discrete observations in diffusion modeling.
  • The methodology provides a robust framework for analyzing complex stochastic systems.