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Fluorescent PARP Inhibitors Applied To Intracranial Glioblastoma: Accumulation and Persistence In Vivo
Zhe Gao1, Zhen Yang2, Zheng Li2
1Department of Chemistry, Texas A & M University, Box 30012, College Station, Texas 77842, United States.
ACS Medicinal Chemistry Letters
|June 16, 2022
Abstract:
Rucaparib-containing fluorescent probes (1-3) inhibit PARP1 in cell models. One of these (1) was tested in a murine model and shown to permeate into implanted intracranial glioblastoma tumors and persist there for at least 24 h.
