Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

29.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.4K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

11.8K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
11.8K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.2K
Pain01:20

Pain

623
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
623
Cranial Nerves: Types Part I01:14

Cranial Nerves: Types Part I

3.1K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.

JDR clinical and translational research·2025
Same author

Mechanics- and Behavior-Related Temporomandibular Joint Differences.

Journal of dental research·2024
Same author

Dental topographic proxies for ecological characteristics in carnivoran mammals.

Journal of anatomy·2023
Same author

Diagnosis and treatment of acute central cervical cord injury.

Chinese medical journal·1999
Same author

[Histological evaluation of collagen-hydroxyapatite composite as osseous implants in the repair of mandibular defect].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·1999
Same author

[A new method to repair artery injuries in extremities by phleboplasty of branched vein graft].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·1999

Related Experiment Video

Updated: Sep 7, 2025

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
09:05

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

7.7K

Chronic Pain-Related Jaw Muscle Motor Load and Sensory Processing.

J C Nickel1,2, Y M Gonzalez2, Y Wu3

  • 1Department of Orthodontics, School of Dentistry, Oregon Health & Science University, Portland, OR, USA.

Journal of Dental Research
|June 16, 2022
PubMed
Summary
This summary is machine-generated.

Chronic pain in temporomandibular disorders (TMDs) is linked to higher jaw muscle activity and sensory processing issues. Increased motor load and physical symptoms predict greater pain intensity in TMD patients.

Keywords:
electromyographymasticatory musclesmyalgiasensory thresholdssomatosensory disorderstemporomandibular joint disorders

More Related Videos

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

1.1K
In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
06:46

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

Published on: November 15, 2024

464

Related Experiment Videos

Last Updated: Sep 7, 2025

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
09:05

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

7.7K
Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
06:37

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

1.1K
In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
06:46

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

Published on: November 15, 2024

464

Area of Science:

  • Biomedical Engineering
  • Pain Medicine
  • Neurology

Background:

  • Chronic pain in temporomandibular disorders (TMDs) may stem from overactive jaw muscles and altered sensory processing.
  • Understanding the relationship between jaw muscle activity, physical symptoms, and pain intensity is crucial for effective TMD management.

Purpose of the Study:

  • To investigate the associations between Characteristic Pain Intensity (CPI), physical symptoms (PHQ-15), and cumulative jaw muscle motor load in individuals with and without TMD myalgia.
  • To identify potential thresholds of muscle activity and sensory processing that correlate with increased pain.

Main Methods:

  • An observational study involving 125 participants diagnosed using the Diagnostic Criteria for TMD (DC-TMD).
  • Electromyography (EMG) was used to measure cumulative jaw muscle motor loads during daytime and nighttime activities.
  • Characteristic Pain Intensity (CPI) and Patient Health Questionnaire-15 (PHQ-15) scores were collected to assess pain and physical symptoms.

Main Results:

  • Individuals with TMD myalgia (+Pain group) exhibited significantly higher CPI and PHQ-15 scores compared to the control group (-Pain group).
  • Cumulative jaw muscle motor loads were significantly higher in the +Pain group, during daytime, and in males compared to females.
  • Regression analyses revealed associations between low-magnitude daytime motor load, PHQ-15, and CPI scores, with nonlinear increases in pain above certain thresholds.

Conclusions:

  • Jaw muscle motor load and physical symptoms are significantly associated with pain intensity in TMD.
  • Elevated muscle activity and sensory processing dysregulation may contribute to the experience of chronic pain in TMD.
  • Identifying specific thresholds of motor load and symptom burden can aid in predicting and managing TMD-related pain.