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Updated: Sep 7, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
Published on: May 13, 2020
Atropisomerism in a polyglutamate-based thermoresponsive alignment medium
Dominic S Schirra1, Philipp Götz1, Matthias Lehmann2
1Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Research and Laboratory Center M3, Technical University of Darmstadt, Alarich-Weiss-Str. 16, 64287 Darmstadt, Germany. cthiele@thielelab.de.
Abstract:
Structure elucidation via residual dipolar couplings (RDCs) relies on alignment media. We report on lyotropic liquid crystals (LLCs) of poly-γ-p-biphenyl(2'-methoxy-2-methyl)methyl-L-glutamate (PBPM3LG). Temperature dependent atropisomerism within the biphenyl group enables the acquisition of multiple RDC-datasets within one sample.
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