Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Flow

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Level Light Therapy Effect on Metabolites Measured by MR Spectroscopy in Patients with Moderate Traumatic Brain Injury: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.

AJNR. American journal of neuroradiology·2025

Same author

Stretched-Pulse Mode-Locked Laser Using Post-Cavity Stretching for Ultrahigh-Speed OCT.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2025

Same author

Label-free full-thickness imaging of porcine vagus nerve fascicular anatomy by polarization-sensitive optical coherence tomography.

Journal of neural engineering·2025

Same author

Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study.

Radiology·2024

Same author

Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.

Scientific reports·2024

Same author

Experimental and Theoretical Model of Single Vessel Minimally Invasive Micro-Laser Ablation: Inducing Microvascular Network Remodeling and Blood Flow Redistribution Without Compromising Host Tissue Function.

Research square·2024

Search research articles

Related Experiment Video

Updated: Sep 7, 2025

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Using the dynamic forward scattering signal for optical coherence tomography based blood flow quantification.

Ahhyun Stephanie Nam, Boy Braaf, Benjamin J Vakoc

|June 16, 2022

Summary

This study introduces dynamic forward-scattering (DFS) flowmetry, a novel optical coherence tomography method analyzing forward-scattered light from red blood cells (RBCs). DFS flowmetry offers advantages in blood flow quantification, particularly in retinal and choroidal vessels.

More Related Videos

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

Published on: August 30, 2017

Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

Related Experiment Videos

Last Updated: Sep 7, 2025

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

Published on: August 30, 2017

Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

Area of Science:

Ophthalmology
Biomedical Optics
Medical Imaging

Background:

Existing optical coherence tomography (OCT) methods for blood flow quantification rely on back-scattered light from red blood cells (RBCs).
These methods can be limited by factors such as vessel orientation and signal attenuation.

Purpose of the Study:

To investigate the potential advantages of using forward-scattered light from RBCs for blood flow measurements.
To introduce and demonstrate dynamic forward-scattering (DFS) flowmetry as a novel OCT-based technique.

Main Methods:

Experimental investigation of light forward-scattering by RBCs for flowmetry.
Development and application of dynamic forward-scattering (DFS) flowmetry.
In vivo demonstration in human retinal and choroidal vasculature.

Main Results:

Forward-scattering based flowmetry is insensitive to vessel orientation when vessels are orthogonal to the imaging beam.
Proof-of-principle demonstrations of DFS flowmetry in human retinal and choroidal vessels were successful.
DFS flowmetry provides a new approach for quantifying blood flow in ocular tissues.

Conclusions:

Dynamic forward-scattering (DFS) flowmetry presents a promising alternative to traditional back-scattering OCT methods for blood flow quantification.
This technique may overcome limitations associated with vessel orientation, enhancing the reliability of blood flow measurements in ophthalmology.
DFS flowmetry has the potential to improve diagnostic capabilities for various vascular conditions affecting the eye.