Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

22.1K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
22.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robust wavefront correction using AdamW-enhanced SPGD for computational adaptive optics in optical coherence tomography.

Biomedical optics express·2026
Same author

Label-free full-thickness imaging of porcine vagus nerve fascicular anatomy by polarization-sensitive optical coherence tomography.

Journal of neural engineering·2025
Same author

Effects of Low-Level Light Therapy on Resting-State Connectivity Following Moderate Traumatic Brain Injury: Secondary Analyses of a Double-blinded Placebo-controlled Study.

Radiology·2024
Same author

Needle guidance with Doppler-tracked polarization-sensitive optical coherence tomography.

Journal of biomedical optics·2023
Same author

Direct Blood Cell Flow Imaging in Microvascular Networks.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same author

Deep learning-based image enhancement in optical coherence tomography by exploiting interference fringe.

Communications biology·2023
Same journal

Optical probe for nondestructive wafer-scale characterization of photonic elements.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2024
Same journal

Two-color Semiconductor Mode-locked Laser system for Multiphoton Imaging Applications.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2023
Same journal

Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2021
Same journal

Glass 3D printing of microfluidic pressure sensor interrogated by fiber-optic refractometry.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2020
Same journal

Fabry-Pérot optical sensor and portable detector for monitoring high-resolution ocular hemodynamics.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2019
Same journal

Buried Rib SiO<sub>2</sub> Multimode Interference Waveguides for Optofluidic Multiplexing.

IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society·2019
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Implementation of a Coherent Anti-Stokes Raman Scattering CARS System on a Ti:Sapphire and OPO Laser Based Standard Laser Scanning Microscope
12:54

Implementation of a Coherent Anti-Stokes Raman Scattering CARS System on a Ti:Sapphire and OPO Laser Based Standard Laser Scanning Microscope

Published on: July 17, 2016

11.2K

Stretched-Pulse Mode-Locked Laser Using Post-Cavity Stretching for Ultrahigh-Speed OCT.

Jongyoon Joo1, Seungwan Cho1, Benjamin J Vakoc2

  • 1Department of Mechanical Engineering and the KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

IEEE Photonics Technology Letters : a Publication of the IEEE Laser and Electro-Optics Society
|April 7, 2025
PubMed
Summary
This summary is machine-generated.

We developed a stretched-pulse mode-locked (SPML) laser using chirped fiber Bragg gratings (CFBG) with post-cavity stretching. This enhances optical coherence tomography (OCT) imaging range and speed without optical buffering.

Keywords:
Optical coherence tomography (OCT)semiconductor laserstunable lasers

More Related Videos

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
07:19

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Published on: June 28, 2017

10.2K
Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.5K

Related Experiment Videos

Last Updated: Apr 12, 2026

Implementation of a Coherent Anti-Stokes Raman Scattering CARS System on a Ti:Sapphire and OPO Laser Based Standard Laser Scanning Microscope
12:54

Implementation of a Coherent Anti-Stokes Raman Scattering CARS System on a Ti:Sapphire and OPO Laser Based Standard Laser Scanning Microscope

Published on: July 17, 2016

11.2K
Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
07:19

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Published on: June 28, 2017

10.2K
Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.5K

Area of Science:

  • Photonics and Optical Engineering
  • Biomedical Imaging Technology
  • Laser Physics

Background:

  • Wavelength-swept lasers are crucial for optical coherence tomography (OCT) imaging.
  • Stretched-pulse mode-locking (SPML) enhances laser performance but can be limited by intra-cavity components.
  • Achieving long coherence lengths in OCT is essential for deep tissue imaging.

Purpose of the Study:

  • To demonstrate a novel chirped fiber Bragg grating (CFBG) based SPML laser incorporating post-cavity stretching.
  • To evaluate the impact of complementary post-cavity stretching on OCT imaging performance, specifically coherence length and sensitivity.
  • To offer a versatile laser source for OCT systems requiring extended imaging ranges.

Main Methods:

  • A stretched-pulse mode-locked (SPML) laser cavity was designed using a 5-m intra-cavity chirped fiber Bragg grating (CFBG).
  • Complementary post-cavity stretching was implemented using an additional 5-m CFBG.
  • The laser's wavelength sweep rate was measured at 1075 nm/μs.
  • Optical coherence tomography (OCT) imaging was performed, measuring sensitivity and coherence length.

Main Results:

  • The CFBG-SPML laser with post-cavity stretching achieved a wavelength sweep rate of 1075 nm/μs.
  • OCT imaging demonstrated a sensitivity of 97.4 dB and a 6-dB coherence length of 5.6 mm.
  • A more than two-fold increase in coherence length was observed compared to intra-cavity stretching alone, with a minimal sensitivity drop of 0.6 dB.

Conclusions:

  • Complementary post-cavity stretching in CFBG-SPML lasers significantly enhances coherence length for OCT imaging.
  • This approach offers versatility in OCT imaging speed and eliminates the need for optical buffering.
  • The developed laser is a compelling option for OCT applications demanding long imaging ranges.