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Updated: Sep 7, 2025

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Calcium-Differentiated Cellular Internalization of Allosteric Framework Nucleic Acids for Targeted Payload Delivery

Jiao Zheng1, Qiwei Wang1, Lin Shi1

  • 1Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

Analytical Chemistry
|June 16, 2022
PubMed
Summary

This study introduces a novel cancer-targeting delivery system using framework nucleic acids (FNAs) that transform in response to the tumor microenvironment. This smart nanovehicle enhances cellular uptake and enables precise mRNA imaging for targeted cancer therapy.

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