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Effect of beetroot or beetroot plus vitamin C supplementation on cardiovascular function in patients with coronary
Leila Sadat Bahrami1,2, Mohsen Mohebaty3, Seyyed Mostafa Arabi1,4
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
This study investigates beetroot and vitamin C supplementation for coronary artery disease (CAD) patients. It aims to improve cardiovascular health markers and function in individuals with atherosclerosis.
Area of Science:
- Cardiology
- Nutritional Science
- Clinical Trials
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Atherosclerosis, the underlying cause of CAD, necessitates effective interventions.
- Current treatments for CAD often have limitations, driving research into novel therapeutic approaches.
Purpose of the Study:
- To evaluate the impact of beetroot and beetroot with vitamin C supplementation on cardiovascular health in CAD patients.
- To assess changes in key cardiovascular function and inflammatory markers.
- To compare the efficacy of beetroot alone versus combined beetroot and vitamin C therapy.
Main Methods:
- A 4-week, randomized, double-blind, placebo-controlled trial involving 90 CAD patients.
- Participants were assigned to receive beetroot capsules, beetroot plus vitamin C capsules, or placebo.
- Measurements included pulse wave velocity, Augmentation Index, VO2 max, blood pressure, inflammatory markers (IL-6, hs-CRP), and lipid profiles.
Main Results:
- The study is designed to measure significant changes in cardiovascular parameters.
- Potential improvements in endothelial function and exercise capacity are anticipated.
- The impact on inflammatory markers and lipid profiles will be analyzed.
Conclusions:
- Findings will elucidate the potential of beetroot and vitamin C as adjunctive therapies for CAD.
- Results may inform clinical practice regarding nutritional interventions for cardiovascular health.
- Further research may be warranted based on the observed effects.
Introduction:
Coronary artery disease (CAD), classified into the atherosclerosis category, is a prevalent cardiovascular disease worldwide that is associated with serious comorbidities and death. The purpose of this study was to evaluate the effect of beetroot/beetroot plus vitamin C on cardiovascular health status and function in patients with CAD.
Method And Analysis:
A randomised, placebo-controlled, double-blind clinical trial to recruit 90 patients with CAD at the cardiac outpatient clinic and Imam Reza Hospital, Mashhad, Iran. Participants will be divided into three groups: (1) Those who receive 500 mg three times a day of beetroot capsules, (2) Those who receive 500 mg three times a day of beetroot plus vitamin C capsules, and (3) Those who receive placebo capsules three times a day for 4 weeks. Pulse wave velocity, Augmentation Index, heart rate, volume of oxygen (VO2) max/VO2 peak, peak heart rate, blood pressure, interleukin 6 (IL-6), high sensitivity C reactive protein, intercellular adhesion molecule, vascular cell adhesion molecule, lipid profile and anthropometry will be measured at the beginning and end of the intervention.
Ethics And Dissemination:
This study was approved by the Ethics Committee of Mashhad University of Medical Sciences (IR.MUMS.MEDICAL.REC.1399.717). All participants will be asked to complete the consent form at the beginning of the study. The results will be actively disseminated through peer-reviewed journals and conference presentations.
Trial Registration Number:
Iranian Registry of Clinical Trials, IRCT20210217050393N1 (registered 16 May 2021).
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