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Updated: Sep 7, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Percutaneous Large Thrombus and Vegetation Evacuation in the Catheterization Laboratory
Madhan Shanmugasundaram1, Arka Chatterjee1, Kwan Lee1
1Section of Cardiology, Department of Internal Medicine, Banner University Medical Center, Sarver Heart Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.
Percutaneous treatments offer alternatives for patients with intracardiac and intravascular thrombi who face surgical challenges. The AngioVac device provides a minimally invasive option for removing thrombi and vegetations.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Device Technology
Background:
- Intracardiac and intravascular thrombi pose significant health risks, leading to high morbidity and mortality.
- Surgical intervention, the traditional treatment, is often complicated by patient comorbidities.
- Advancements in catheter-based techniques are introducing less invasive therapeutic options.
Purpose of the Study:
- To review the application and efficacy of the AngioVac device for percutaneous removal of intravascular and intracardiac thrombi.
- To highlight the AngioVac's role as an alternative in complex patient populations.
Main Methods:
- The AngioVac is a Food and Drug Administration (FDA)-approved, percutaneous, vacuum-assisted thrombectomy device.
- It operates within a venovenous extracorporeal membranous oxygenation circuit, incorporating a filtration system.
- Case reports and existing literature on AngioVac utilization were reviewed.
Main Results:
- The AngioVac has demonstrated utility in removing right atrial and iliocaval thrombi.
- It has been successfully used for debulking tricuspid valve vegetations and removing vegetations from cardiac implantable devices.
- Applications also extend to managing pulmonary embolism.
Conclusions:
- The AngioVac represents a viable percutaneous option for managing challenging intracardiac and intravascular thrombi.
- Its use expands treatment possibilities for patients with contraindications to traditional surgery.
- Further research may solidify its role in various thrombotic and embolic conditions.
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