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Intravascular Large B Cell Lymphoma - Still a Diagnostic Dilemma
Abuzar A Asif1, Manisha Tharoor1, Jacqueline L Fischer1
1Department of Internal Medicine, University of Illinois College of Medicine, Peoria, IL, USA.
Summary
Intravascular large B cell lymphoma (IVLBCL) is a rare cancer that is hard to diagnose. This case highlights IVLBCL presenting as endocrinopathy, leading to fatal multiorgan failure.
Area of Science:
- Hematology
- Oncology
- Endocrinology
Background:
- Intravascular large B cell lymphoma (IVLBCL) is a rare and aggressive non-Hodgkin lymphoma.
- IVLBCL is characterized by the proliferation of lymphoma cells within the lumens of small blood vessels.
- Diagnosis is challenging due to non-specific symptoms and rarity.
Observation:
- An 81-year-old woman presented with predominant endocrinopathy.
- Her symptoms were initially attributed to endocrine dysfunction.
- Despite extensive workup, the underlying cause remained elusive during her lifetime.
Findings:
- The patient succumbed to multiorgan failure.
- Postmortem autopsy confirmed the diagnosis of intravascular large B cell lymphoma (IVLBCL).
- This case underscores the rare presentation of IVLBCL with endocrinologic abnormalities.
Implications:
- Highlights the importance of considering rare diagnoses like IVLBCL in patients with unexplained endocrinopathy.
- Emphasizes the diagnostic challenges associated with IVLBCL, particularly in atypical presentations.
- Suggests that endocrinopathy can be a critical, albeit rare, initial manifestation of IVLBCL, impacting patient outcomes.
