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Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies.

Valencia Hui Xian Foo1,2, Jodhbir Mehta1,2,3, Anita Sook Yee Chan1,2,3

  • 1Singapore National Eye Centre, Singapore, Singapore.

Frontiers in Medicine
|June 17, 2022
PubMed
Summary
This summary is machine-generated.

Peripheral ulcerative keratitis (PUK) can be a rare paraneoplastic complication of systemic solid tumors. Early ophthalmological review is crucial for timely intervention in patients with malignancies and inflamed eyes.

Keywords:
cornealinflammationmalignancyparaneoplasticperipheral ulcerative keratitis

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Peripheral ulcerative keratitis (PUK) is an inflammatory eye condition.
  • PUK can be associated with systemic autoimmune diseases and infections.
  • This study investigates PUK as a potential paraneoplastic manifestation of solid tumors.

Observation:

  • A case series of three patients with PUK and underlying systemic solid tumor malignancies is presented.
  • Patients had recurrent breast cancer, metastatic thyroid cancer, and metastatic gastric adenocarcinoma.
  • All patients presented with significant corneal stromal melt and negative autoimmune/infective workups.

Findings:

  • Peripheral ulcerative keratitis (PUK) can manifest as a rare paraneoplastic complication of systemic solid tumors.
  • Treatment with topical steroids and intravenous methylprednisolone was effective.
  • One patient experienced recurrent PUK requiring amniotic grafts and keratoplasties.

Implications:

  • This case series underscores the importance of considering PUK as a paraneoplastic phenomenon in cancer patients.
  • Prompt ophthalmological evaluation is essential for early diagnosis and management of sight-threatening PUK.
  • Timely intervention can potentially improve visual outcomes in these patients.