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Intraocular Inflammation After Intravitreal Faricimab Injections: A Case Series.

Yunhua Loo1, Joshua Lim1, Milton Cher Yong Chew1

  • 1Singapore National Eye Centre, Singapore.

Clinical & Experimental Ophthalmology
|January 24, 2026
PubMed
Summary
This summary is machine-generated.

Intraocular inflammation (IOI) can occur after faricimab injections, presenting as hypertensive uveitis. Prompt management of intraocular pressure is crucial to prevent vision loss.

Keywords:
Vabysmoanti‐VEGFfaricimabintraocular inflammationintravitreal injections

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacology

Background:

  • Intraocular inflammation (IOI) is a rare but serious complication following intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.
  • The incidence of IOI has increased, particularly with newer anti-VEGF agents.
  • Faricimab is a recently approved anti-VEGF medication with ongoing safety data collection.

Purpose of the Study:

  • To report cases of intraocular inflammation (IOI) following intravitreal faricimab injections.
  • To characterize the clinical presentation and outcomes of IOI after faricimab use.

Main Methods:

  • Retrospective case series.
  • Involved 8 eyes from 5 patients who developed IOI after faricimab intravitreal injections.

Main Results:

  • All patients presented with significant uveitis and anterior vitreous involvement.
  • Four patients developed subacute hypertensive uveitis; one had acute presentation with normal intraocular pressure.
  • Inflammation resolved in all patients after discontinuing faricimab and initiating anti-inflammatory treatment.

Conclusions:

  • Non-infectious hypertensive uveitis can occur following intravitreal faricimab injections.
  • Prompt management of intraocular pressure is essential to prevent glaucomatous damage.
  • Distinguishing IOI from infectious endophthalmitis is critical to avoid inappropriate antibiotic and surgical interventions.