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Lipokathexis: A fat paradox.

Sanjay Kalra1, Saurabh Arora2, Nitin Kapoor3

  • 1Department of Endocrinology, Bharti Hospital, Karnal, India.

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|June 17, 2022
PubMed
Summary

Lipokathexis describes a paradox where individuals have high body fat but low blood lipid levels. This condition, seen in diseases like Tangier

Keywords:
Cholesterol, dyslipidemia, hyperlipidemia, LDL cholesterol, myelokathexis, Tangier's disease.

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Area of Science:

  • Metabolic Medicine
  • Lipid Metabolism
  • Clinical Phenotyping

Background:

  • Excessive adipose tissue accumulation is typically associated with dyslipidemia.
  • However, certain conditions present with high body fat and paradoxically low circulating lipids.
  • Understanding this disconnect is crucial for metabolic health assessment.

Purpose of the Study:

  • To introduce and define the term 'Lipokathexis' for a specific clinical phenotype.
  • To explore the underlying mechanisms of lipid dysregulation in this condition.
  • To highlight the clinical relevance of the 'Fat Paradox' in metabolic medicine.

Main Methods:

  • Literature review of conditions exhibiting the lipokathexis phenotype.
  • Analysis of lipid metabolism pathways in relation to fat storage.
  • Clinical case examples illustrating the 'Fat Paradox'.

Main Results:

  • Lipokathexis is characterized by high adiposity and low serum lipid levels.
  • Conditions such as Tangier's disease and metabolically healthy obesity exemplify this phenotype.
  • The 'Fat Paradox' challenges conventional understanding of lipid-obesity relationships.

Conclusions:

  • Lipokathexis represents a distinct clinical scenario requiring further investigation.
  • This concept broadens the understanding of lipid metabolism and obesity.
  • Further research into lipokathexis may reveal novel therapeutic targets for metabolic disorders.