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Updated: Sep 7, 2025

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
Published on: August 10, 2017
Towards 'end-to-end' analysis and understanding of biological timecourse data
Siddhartha G Jena1, Alexander G Goglia2, Barbara E Engelhardt3,4
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, U.S.A.
Abstract:
Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets.
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