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Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Programmed cell death detection methods: a systematic review and a categorical comparison.

Sana Kari1, Kumar Subramanian1, Ilenia Agata Altomonte1

  • 1Molecular Signaling Lab, Faculty of Medicine and Health Technology, Tampere University, P.O. Box 553, 33101, Tampere, Finland.

Apoptosis : an International Journal on Programmed Cell Death
|June 17, 2022
PubMed
Summary

Programmed cell death, including apoptosis, is vital for biological processes and cancer research. This review compares methods for detecting cell death, aiding researchers in selecting effective assays.

Keywords:
ApoptosisBiomarkersCaspaseDNA fragmentationELISAElectrophoresisHallmarksImmunohistochemistryNecroptosisPyroptosis

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Programmed cell death regulates tissue growth, embryogenesis, and immune responses.
  • Apoptosis is crucial in cancer research for understanding cell cycle arrest and developing targeted therapies.
  • Identifying cell death hallmarks and biomarkers aids in drug development for cancer treatment.

Purpose of the Study:

  • To critically review and categorize mechanisms of programmed cell death.
  • To systematically analyze conventional and unconventional detection methods.
  • To provide a comparative analysis of cell death detection assays.

Main Methods:

  • Systematic review of programmed cell death mechanisms.
  • Categorization based on morphological hallmarks and biomarkers.
  • Comparative analysis of detection methods' principles, applications, advantages, and disadvantages.

Main Results:

  • Different programmed cell death types have distinct morphological and molecular hallmarks.
  • Various serological and microscopic techniques exist, each with limitations.
  • A comprehensive comparison highlights efficient and effective detection methods.

Conclusions:

  • Accurate detection of programmed cell death is challenging due to mechanistic complexity.
  • Selection of appropriate cell death assays is crucial for reliable research outcomes.
  • Improvements in detection methods can offer insights into distinct cell death stages.