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Updated: Sep 7, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Defining 'normal': Methodological issues in Aphasia and intelligence research.

Marjorie Perlman Lorch¹

¹Department of Languages, Cultures and Applied Linguistics, School of Arts Birkbeck, University of London, London, United Kingdom.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior

|June 17, 2022

Summary

Standardized tests were developed to study language and intellectual impairments in individuals with aphasia. This research introduced the innovative concept of a matched control group for neuropsychological assessment.

Keywords:

Aphasia Assessment Control group Methodology Normal

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Area of Science:

Neuropsychology
Clinical Psychology
Psychometrics

Background:

Henry Head's aphasia tests (1926) presented challenges.
Theodore H. Weisenburg initiated a research program in 1927 to address these issues.

Purpose of the Study:

To develop standardized tests for investigating language and intellectual impairments.
To characterize 'normal' cognitive function through a matched control group.

Main Methods:

Development of a new battery of tests for individuals with aphasia.
Introduction of a matched control group including neurological and non-neurological participants.
Inclusion of participant variables such as age, education, and socioeconomic status.

Main Results:

Identification of crucial participant variables for accurate assessment.
Establishment of a representative control sample using population statistics.
Methodological innovations in neuropsychological test development.

Conclusions:

Weisenburg's work significantly advanced neuropsychological testing.
The study's innovations continue to influence clinical testing and research design.
The concept of matched control groups remains a cornerstone in neuropsychological research.