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Ondansetron/Cyclodextrin inclusion complex nanofibrous webs for potential orally fast-disintegrating antiemetic drug

Emmy Hsiung1, Asli Celebioglu1, Mehmet Emin Kilic2

  • 1Fiber Science Program, Department of Human Centered Design, College of Human Ecology, Cornell University, Ithaca, NY 14853, USA.

International Journal of Pharmaceutics
|June 17, 2022
PubMed

Insights

This study developed polymer-free nanofibrous webs of ondansetron (ODS) and hydroxypropyl-beta-cyclodextrins (HPβCD) for enhanced oral drug delivery. The ODS/HPβCD webs offer rapid disintegration and improved drug release, presenting a promising alternative to traditional polymeric systems.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Ondansetron (ODS) exhibits poor oral bioavailability due to low solubility and first-pass metabolism.
  • Cyclodextrins (CDs) can improve drug solubility and bioavailability through inclusion complexation.
  • Polymeric systems often face limitations in drug delivery applications.

Purpose of the Study:

  • To develop polymer-free, free-standing ondansetron/cyclodextrin nanofibrous webs (NW) for fast-disintegrating oral delivery.
  • To investigate the use of hydroxypropyl-beta-cyclodextrins (HPβCD) as both a complexation agent and electrospinning matrix.
  • To evaluate the drug loading, release profile, and disintegration properties of the ODS/HPβCD NW.

Main Methods:

  • Electrospinning of polymer-free ODS/HPβCD nanofibrous webs.
  • Computational study to determine optimal drug/CD stoichiometry (1/2 favored).
  • Characterization of loading efficiency, drug distribution, release profile, and disintegration time.

Main Results:

  • ODS/HPβCD NW achieved high loading efficiency (~96%) compared to ODS/PVA NW (~80%).
  • Complexation resulted in amorphous distribution of ODS, enhancing solubility and release.
  • ODS/HPβCD NW exhibited rapid disintegration (~2 seconds) in artificial saliva.

Conclusions:

  • Polymer-free ODS/HPβCD NW represent a promising fast-disintegrating oral drug delivery system.
  • This approach mitigates ODS solubility and bioavailability issues without toxic solvents.
  • ODS/HPβCD NW offer a viable alternative to polymeric systems for enhanced antiemetic drug delivery.
Keywords:
Antiemetic treatmentCyclodextrinElectrospinningFast disintegratingOndansetronOral drug delivery

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