Recyclable Luminescent Sensor for Detecting Creatinine Based on a Lanthanide-Organic Framework.

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Creatinine is a vital clinical biomarker for assessing human health.
• Developing sensitive luminescent sensors for creatinine detection remains an area of active research.
• Metal-organic frameworks (MOFs) offer unique properties for sensing applications.

Purpose of the Study:

• To synthesize and characterize a novel lanthanide-organic framework (LOF).
• To investigate the potential of the synthesized LOF as a luminescent sensor for creatinine detection.
• To evaluate the sensor's performance in aqueous solutions and biological samples.

Main Methods:

• Synthesis of a new lanthanide-organic framework, {[Tb(L)(CH3COO)(H2O)]·0.5DMF} (1), where H2L = 3,5-bis(4'-carboxy-phenyl)1,2,4-triazole.
• Characterization of the framework's stability in various conditions (solvent, pH).
• Luminescence-based detection of creatinine in aqueous solutions and diluted serum samples.

Main Results:

• The synthesized LOF (1) exhibited excellent solvent and acid/alkaline stabilities.
• The sensor demonstrated a wide linear detection range for creatinine (3.27–371 μM) with a low detection limit (1.7 × 10⁻⁶ M).
• The sensor successfully monitored creatinine concentrations in diluted serum and was recyclable for at least five cycles.

Conclusions:

• The novel lanthanide-organic framework serves as an effective luminescent sensor for creatinine.
• The sensor's high sensitivity, wide detection range, and reusability indicate its potential for clinical creatinine monitoring.
• This work expands the application of MOFs in sensitive and selective biomolecule detection.