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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Related Experiment Video

Updated: Jun 14, 2026

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
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Nanoparticle Self-Assembly: From Design Principles to Complex Matter to Functional Materials.

Anish Rao1, Sumit Roy1, Vanshika Jain1

  • 1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Dr. Homi Bhabha Road, Pashan, Pune 411 008, India.

ACS Applied Materials & Interfaces
|June 17, 2022
PubMed
Summary

Controlling nanoparticle self-assembly is key to creating complex materials. Understanding design principles and predicting outcomes, even beyond equilibrium states, is crucial for next-generation functional matter.

Keywords:
catalysismacroscopic devicesnanoparticlesnanoscale forcesself-assembly

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Self-assembly aims to create complex matter with specific functions.
  • Controlling component interactions is vital for successful self-assembly.
  • Current methods often rely on equilibrium states, limiting complex structure formation.

Purpose of the Study:

  • To review the role of interparticle interactions in nanomaterial self-assembly.
  • To highlight design principles and predictive capabilities for nanoparticle assemblies.
  • To explore the potential for creating complex and functional matter beyond equilibrium.

Main Methods:

  • Review of existing literature on nanoparticle self-assembly.
  • Analysis of design principles for controlling self-assembly pathways.
  • Summary of diverse self-assembled structures and their emergent properties.

Main Results:

  • Finely tuned interparticle interactions are essential for achieving desired self-assembled structures.
  • Predictive models for nanoparticle self-assembly can guide the creation of complex matter.
  • Nanoparticle assemblies exhibit a wide range of functional properties.

Conclusions:

  • A deeper understanding of design and prediction in nanoparticle self-assembly is needed.
  • This approach could revolutionize the creation of complex matter, akin to retrosynthesis in chemistry.
  • Future challenges include creating complex, evolvable matter and overcoming limitations of equilibrium-based assembly.