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Study protocol: assessing SleeP IN infants with early-onset atopic Dermatitis by Longitudinal Evaluation (The SPINDLE
Cathal O'Connor1,2,3, Alan D Irvine4,5,6, Deirdre Murray7,4
1Department of Paediatrics and Child Health, Cork University Hospital, Cork, Ireland. cathal.oconnor@ucc.ie.
BMC Pediatrics
|June 18, 2022
Summary
Infants with atopic dermatitis (AD) experience significant sleep disturbances impacting development. This study details their sleep architecture using advanced methods to inform better AD management and improve infant sleep quality.
Area of Science:
- Pediatric Dermatology
- Sleep Medicine
- Developmental Neuroscience
Background:
- Atopic dermatitis (AD) is a common childhood inflammatory skin condition.
- Sleep disturbances affect 50-60% of children with AD due to itch, dryness, and inflammation.
- Early-life sleep disruption is linked to later cognitive and psychological issues.
Purpose of the Study:
- To detail the sleep architecture of infants with early-onset atopic dermatitis (AD).
- To compare sleep patterns in infants with AD versus healthy controls.
- To investigate the impact of AD on infant sleep quality and development.
Main Methods:
- Observational study of 6-8 month old infants with moderate-to-severe AD and age-matched controls.
- Diurnal EEG polysomnography and nocturnal sleep actigraphy over 12 months.
- Monthly questionnaires for sleep data, plus skin barrier, immune, and neurodevelopmental assessments.
Main Results:
- The study is designed to analyze sleep macro- and microstructures.
- It will assess disturbed sleep in infants and their parents.
- Skin barrier and immune profiles will be correlated with sleep patterns.
Conclusions:
- This research offers a detailed analysis of infant sleep in the first year of life with AD.
- Findings may guide optimal AD treatment to mitigate sleep disruption.
- Understanding sleep architecture in infants with AD is crucial for developmental outcomes.
Keywords:
ActigraphyAtopic dermatitisEarly interventionElectroencepalographyParental sleep disruptionSleepSleep diariesSleep disruption
