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Circulating long noncoding RNAs as novel bio-tools: Focus on autoimmune diseases
Bahareh Karimi1, Ali Dehghani Firoozabadi2, Maryam Peymani3
1Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Human Immunology
|June 18, 2022
Summary
Circulating long non-coding RNAs (lncRNAs), especially those within exosomes, show potential as diagnostic biomarkers for autoimmune diseases. These molecules offer a stable and accessible method for disease detection and prognosis.
Area of Science:
- Molecular Biology
- Immunology
- Biochemistry
Background:
- Long non-coding RNAs (lncRNAs) are key regulators with altered expression in various diseases.
- Circulating lncRNAs, particularly exosomal lncRNAs, are stable and resistant to degradation.
- Exosomes mediate intercellular communication and play roles in autoimmune pathogenesis.
Purpose of the Study:
- To review the role of circulating lncRNAs, specifically exosomal lncRNAs, as diagnostic biomarkers for autoimmune diseases.
- To highlight their potential in disease prognosis and monitoring.
Main Methods:
- Literature review of studies investigating circulating and exosomal lncRNAs in autoimmune diseases.
- Analysis of the diagnostic and prognostic value of these biomarkers.
Main Results:
- Circulating lncRNAs, especially exosomal forms, are implicated in modulating immune responses in autoimmune conditions.
- These molecules have demonstrated potential as diagnostic and prognostic biomarkers for rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, and Sjögren's syndrome.
Conclusions:
- Exosomal lncRNAs represent promising, stable biomarkers for the diagnosis and prognosis of autoimmune diseases.
- Further research into circulating lncRNAs could revolutionize autoimmune disease management.
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