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Updated: Aug 5, 2026
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Identification of OncoMir Biomarkers: Comprehensive Analysis of Fatty Acid Pathway Genes in Colorectal Cancer
Andisheh Oroujalian1, Maryam Keshani2, Farnoush Panahi2
1Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, P.O. Box: 8813733395, Iran.
Abstract:
MicroRNAs play a pivotal role in driving colorectal cancer (CRC) progression through their influence on gene expression. In this study, we conducted a comprehensive analysis of gene expression profiles in CRC cell lines, focusing on the genes involved in the fatty acid pathway and their associated microRNAs. Our analysis unveiled a consistent pattern of decreased expression for miR-16-5p, miR-195-5p, miR-27a-3p, and miR-497-5p across all CRC cell lines studied. Intriguingly, the targeted genes showed a contrasting trend, with increased expression levels. To reinforce our findings, we conducted a comparative analysis with The Cancer Genome Atlas database, which corroborated our results. Notably, we found a strong association between high expression levels of PPARD and VEGFA and a shorter Disease-Free Survival (DFS) in CRC patients. Conversely, elevated expression of PPARGC1A was linked to better overall survival outcomes. These findings underscore the significant impact of microRNAs on the regulation of gene expression in colorectal cancer and highlight potential biomarkers for assessing disease progression and patient outcomes.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s12291-024-01261-5.
