Related Experiment Video
Updated: Sep 7, 2025
05:14
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
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Myocardial Dysfunction in Patients with Cancer.
Efstratios Koutroumpakis1, Nikhil Agrawal2, Nicolas L Palaskas1
1Department of Cardiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1451, Houston, TX 77030, USA.
Heart Failure Clinics
|June 19, 2022
Summary
Cancer patients often experience myocardial dysfunction due to cancer therapies, leading to significant morbidity and mortality. This review covers cancer-related heart problems and expert recommendations for surveillance and management in cardio-oncology.
Area of Science:
- Cardio-oncology
- Cardiovascular Medicine
- Oncology
Background:
- Myocardial dysfunction is a critical issue in cancer patients, significantly impacting morbidity and mortality.
- Cancer therapies are a major contributor to the development of cardiomyopathy in this population.
- Various conditions including cardiac amyloidosis, malignancies, atherosclerosis, and hypertension exacerbate myocardial dysfunction in cancer patients.
Purpose of the Study:
- To summarize current knowledge on the mechanisms of myocardial dysfunction in cancer patients undergoing cancer-related therapies.
- To outline expert recommendations for the surveillance and management of cancer therapy-related myocardial dysfunction.
Main Methods:
- Literature review and synthesis of current knowledge.
- Consensus-based recommendations from experts in cardio-oncology.
Main Results:
- Detailed mechanisms of myocardial dysfunction in cancer and its treatments are discussed.
- Key recommendations for monitoring and managing cardiotoxicity are provided.
Conclusions:
- Understanding the mechanisms of myocardial dysfunction is crucial for effective patient management.
- Proactive surveillance and management strategies are essential for improving outcomes in cancer patients with therapy-related cardiotoxicity.
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