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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Related Experiment Video

Updated: Sep 7, 2025

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
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Filler-induced blindness "seen" by ophthalmologists: Case presentation and treatment algorithm.

A Martel1, J Lagier1, E Sarfati2

  • 1Ophthalmology department, University Hospital of Nice, Cote d'Azur University, 30, voie romaine, 06000 Nice, France.

Journal Francais D'Ophtalmologie
|June 19, 2022
PubMed
Summary

Filler-induced blindness (FIB) is a severe complication of periocular injections. This case report details a new treatment algorithm for FIB, leading to partial visual recovery using fluorescein angiography.

Keywords:
Acide hyaluroniqueAngiographieAngiographyBlindnessCécitéFillerHyaluronic acidHyperbaric oxygenInjection péribulbaireOxygène hyperbarePeribulbar injection

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Area of Science:

  • Ophthalmology
  • Vascular Surgery

Background:

  • Filler-induced blindness (FIB) is a critical complication of periocular injections, lacking a standardized treatment protocol.
  • Early recognition and intervention are crucial for managing vision loss following cosmetic procedures.

Observation:

  • A case of complete vision loss after forehead lipofilling was reported.
  • Retinal angiography revealed a posterior ciliary artery occlusion.

Findings:

  • Treatment included antiplatelet medication, steroids, IOP-lowering drugs, and hyperbaric oxygen therapy (HBOT).
  • Fluorescein angiography guided HBOT, resulting in partial visual acuity improvement to +0.8 logMar.
  • A personalized FIB treatment algorithm based on fluorescein angiography was developed.

Implications:

  • Physicians must be prepared to manage FIB with prompt, protocol-guided treatment and emergency kits.
  • Referral centers should utilize personalized, angiography-guided approaches for optimal outcomes in FIB management.