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Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573.

C-L Wu1, O N Nfor, W-Y Lu

  • 1Yung-Po Liaw, No. 110 Sec. 1 Jianguo N. Road, Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City- 40201, Taiwan; Tel: +886436097722 ext. 11838; fax: +886423248179,

The Journal of Nutrition, Health & Aging
|June 19, 2022
PubMed
Summary

Coffee consumption may reduce osteoporosis risk in individuals with the ESR1 rs2982573 gene variant. This genetic profile, combined with regular coffee intake, showed a significant association with lower osteoporosis incidence in Taiwanese adults.

Keywords:
Osteoporosisbonebone mineral densitycoffee drinkingpolymorphism

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Area of Science:

  • Genetics and Environmental Health
  • Bone Metabolism and Osteoporosis Research

Background:

  • Osteoporosis development is influenced by a complex interplay of genetic predisposition and lifestyle factors.
  • The ESR1 rs2982573 single nucleotide polymorphism (SNP) is a potential genetic determinant in bone health.

Purpose of the Study:

  • To investigate the association between coffee consumption and osteoporosis risk in individuals carrying the ESR1 rs2982573 variant.
  • To explore potential gene-environment interactions influencing osteoporosis in a Taiwanese population.

Main Methods:

  • A population-based cross-sectional study utilizing genetic, demographic, and lifestyle data from the Taiwan Biobank (TWB).
  • Multiple logistic regression analyses were employed to assess the relationship between osteoporosis, ESR1 rs2982573 genotypes (TT, TC, CC), and coffee consumption.
  • Subgroup analyses were conducted to examine interaction effects.

Main Results:

  • No significant direct association was found between the ESR1 rs2982573 genotype and osteoporosis risk.
  • Coffee consumption was significantly associated with a reduced risk of osteoporosis (OR, 0.737; p=0.006).
  • A significant interaction (p=0.0393) was observed: individuals with the TC+CC genotype who drank coffee had a lower osteoporosis risk (OR, 0.635) compared to TT genotype counterparts, while non-coffee drinkers with TC+CC did not show this protective effect.

Conclusions:

  • The ESR1 rs2982573 genotype interacts with coffee consumption to influence osteoporosis risk.
  • Consuming at least three cups of coffee weekly may mitigate osteoporosis risk in Taiwanese individuals with the TC+CC genotype of ESR1 rs2982573.