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Subtle hyperthyroidism presenting as suspected hepatobiliary disease.

N Shetty, M Camilleri, D W Moss

    Journal of Clinical Gastroenterology
    |April 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Elevated alkaline phosphatase may indicate hyperthyroidism. This study highlights how increased hepatic and bony isoenzymes, alongside a nonspecific history, led to diagnosing hyperthyroidism in three patients, suggesting it as a potential diagnostic clue.

    Area of Science:

    • Endocrinology
    • Hepatology
    • Biochemistry

    Background:

    • Hepatobiliary disorders often present with nonspecific clinical signs.
    • Elevated serum alkaline phosphatase (SAP) is a common indicator of liver or bone disease.

    Observation:

    • Three patients presented with nonspecific symptoms and elevated SAP levels.
    • Isoenzyme analysis revealed elevations in both hepatic and bony isoenzymes.

    Findings:

    • Hyperthyroidism was diagnosed in all three patients.
    • The pattern of elevated isoenzymes was a key diagnostic indicator.

    Implications:

    • Isolated elevation of SAP, particularly with specific isoenzyme patterns, can be an early clue for hyperthyroidism.

    Related Experiment Videos

  • Clinicians should consider hyperthyroidism in the differential diagnosis of unexplained elevated SAP.
  • This finding may improve the early recognition and management of hyperthyroidism.