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Related Concept Videos

Role of Septins01:02

Role of Septins

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
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Post-translational Translocation of Proteins to the RER01:27

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A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
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Translocation of Proteins into the Mitochondria01:19

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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Bacterial Translocation and Protein Secretion01:26

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Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...
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Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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Related Experiment Video

Updated: Sep 7, 2025

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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High Mobility Group Proteins in Sepsis.

Guibin Liang1, Zhihui He1

  • 1Department of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Immunology
|June 20, 2022
PubMed
Summary
This summary is machine-generated.

High mobility group proteins (HMGs) are key inflammatory mediators in sepsis. Understanding HMGs offers new therapeutic targets to reduce sepsis mortality.

Keywords:
drugshigh mobility groupnon-coding RNAsprogrammed cell deathproteinsepsis

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Area of Science:

  • Molecular Biology
  • Immunology
  • Pathophysiology

Background:

  • Sepsis is a life-threatening systemic inflammatory response to infection.
  • High mobility group proteins (HMGs) are nuclear proteins that act as pro-inflammatory cytokines.
  • Elevated HMG levels are observed in sepsis, indicating their role in the disease.

Purpose of the Study:

  • To review the structure and function of HMGs.
  • To summarize sepsis epidemiology and pathophysiology.
  • To explore HMG-related mechanisms in sepsis for diagnostic and therapeutic insights.

Main Methods:

  • Literature review of HMGs and sepsis.
  • Analysis of HMGs' role in inflammation and gene regulation.
  • Examination of HMGs in relation to non-coding RNAs and programmed cell death.

Main Results:

  • HMGs are potent mediators of inflammation and contribute to sepsis pathophysiology.
  • HMGs are implicated in various cellular processes relevant to sepsis, including programmed cell death.
  • Non-coding RNAs modulate HMG expression and function in sepsis.

Conclusions:

  • HMGs are crucial players in sepsis pathogenesis.
  • Targeting HMGs presents a promising strategy for sepsis treatment.
  • Further research into HMGs and related pathways can improve sepsis diagnosis and management.