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Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions

Si-Yue Zhai1,2, Michael G Kong2,3, Yu-Min Xia1

  • 1Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Frontiers in Immunology
|June 20, 2022
PubMed

Insights

Cold atmospheric plasma (CAP) offers a novel, non-invasive treatment for various skin conditions. This innovative therapy effectively combats infections, promotes wound healing, and manages inflammatory diseases and cancers.

Area of Science:

  • Dermatology and plasma medicine.
  • Investigating the therapeutic applications of cold atmospheric plasma (CAP) in skin disease treatment.

Background:

  • Traditional skin disease therapies often yield unsatisfactory results due to side effects and recurrence.
  • Pathogenesis of skin diseases involves microbial infections, autoimmune responses, aberrant cell proliferation, and inflammation.

Purpose of the Study:

  • To review recent advancements in cold atmospheric plasma (CAP) therapies for diverse skin diseases.
  • To explore future strategies for enhancing CAP effectiveness and expanding clinical applications.

Main Methods:

  • Review of current scientific literature on cold atmospheric plasma (CAP) applications in dermatology.
  • Analysis of CAP's mechanisms, including reactive oxygen and nitrogen species generation.

Main Results:

  • Cold atmospheric plasma (CAP) demonstrates significant efficacy in treating bacterial, viral, and fungal skin infections.
  • CAP facilitates wound healing, inhibits cancer cell proliferation, and ameliorates conditions like psoriasis and vitiligo.
  • CAP is a safe and effective non-invasive therapeutic approach for dermatological conditions.

Conclusions:

  • Cold atmospheric plasma (CAP) presents a promising therapeutic modality for a wide range of skin diseases.
  • Further research is warranted to optimize CAP treatments and broaden their clinical use in dermatology.
Keywords:
cold atmospheric plasmareactive nitrogen speciesreactive oxygen speciesskin diseasetherapy

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