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Updated: Sep 7, 2025
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Visuospatial and Executive Dysfunction in Patients With Acute Kidney Injury, Chronic Kidney Disease, and Kidney
Natasha A Jawa1, Jessica A Vanderlinden1, Stephen H Scott1,2
1Centre for Neuroscience Studies, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Canadian Journal of Kidney Health and Disease
|June 20, 2022
Summary
Robotic assessment revealed that patients with acute kidney injury (AKI) exhibit worse neurocognitive function, particularly in executive function and visuomotor control, compared to those with chronic kidney disease (CKD) or kidney failure.
Area of Science:
- Nephrology
- Neuroscience
- Biomedical Engineering
Background:
- Neurocognitive impairment is prevalent in kidney disease, impacting quality of life.
- Robotic technology can detect subtle neurocognitive deficits missed by traditional tests.
- Previous research showed robotic assessment utility in acute kidney injury (AKI) and chronic kidney disease (CKD).
Purpose of the Study:
- To determine if neurocognitive deficits differ among patients with AKI, CKD, or kidney failure.
- To compare robotic assessment findings across different kidney disease diagnostic groups.
- To investigate the interaction between kidney disease type and neurocognitive task performance.
Main Methods:
- Cross-sectional analysis of 104 adult participants with AKI, CKD (G3-5), or kidney failure.
- Robotic neurocognitive assessment using the Kinarm device, evaluating upper limb movement tasks.
- Multilevel modeling to analyze the effects of Kinarm task type and kidney diagnostic group on performance.
Main Results:
- Participants performed worst on Reverse Visually Guided Reaching, Visually Guided Reaching, and Trail Making tasks across all kidney groups.
- No significant differences in average performance were found across kidney diagnostic groups for most tasks.
- Patients with AKI showed significantly worse performance than CKD or kidney failure patients on the Reverse Visually Guided Reaching task.
Conclusions:
- Robotic assessment using Kinarm identified specific neurocognitive deficits in kidney disease patients.
- Acute kidney injury (AKI) patients demonstrated poorer executive function and visuomotor control compared to CKD or kidney failure patients.
- The findings highlight the sensitivity of robotic assessment in differentiating neurocognitive impairment severity across kidney disease spectrums.
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