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Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation
Ali Mala1, Yameena Noman Khan1, Akbar Ahmed1
1Indus Hospital and Health Network, Plot C-76, Sector 31/5, Opposite Darussalam Society Korangi Crossing, Karachi 75190, Pakistan.
Case Reports in Hematology
|June 20, 2022
Summary
Plasmablastic lymphoma (PBL) is a rare, aggressive cancer. This case highlights PBL in an immunocompetent child, emphasizing the need for broader diagnostic considerations in pediatric oncology.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma.
- PBL is strongly associated with HIV infection and immunocompromised states.
- Rare cases occur in immunocompetent individuals.
Observation:
- A healthy, immunocompetent child presented with leg swelling and pain.
- Histopathology revealed neoplastic cells replacing bone marrow with sclerotic bone fragments.
- Large, monomorphic, multinucleated neoplastic cells and pleomorphic cells were observed.
Findings:
- The case was diagnosed as tibial plasmablastic lymphoma.
- The patient received a FAB/LMB96 group C chemotherapy regimen.
- Significant clinical improvement was noted post-chemotherapy.
Implications:
- This case expands the understanding of PBL presentation in immunocompetent pediatric patients.
- Highlights the importance of considering rare diagnoses in pediatric oncology.
- Suggests chemotherapy efficacy in pediatric tibial plasmablastic lymphoma.
