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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
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Establishment of normal reference range for thromboelastography based on 17,708 cases in Beijing, China
Chao Wei1, Jin-Yang Zhao1, Shu-Ying Wang2
1Department of Blood Transfusion Medicine, Electric Power Teaching Hospital, Capital Medical University, Beijing, China.
Annals of Translational Medicine
|June 20, 2022
Summary
This study establishes normal Thromboelastography (TEG) reference ranges for the Beijing population, revealing significant differences in coagulation activity based on age and sex. These findings are crucial for accurate interpretation of TEG results in diverse patient groups.
Area of Science:
- Hematology
- Clinical Pathology
- Biomedical Engineering
Background:
- Thromboelastography (TEG) assesses blood coagulation dynamics, including platelet and plasma factor interactions.
- Establishing local reference ranges for TEG is essential due to regional variations in disease incidence and coagulation status.
- Previous studies highlight the need for region-specific TEG normal values.
Purpose of the Study:
- To determine local normal reference ranges for TEG parameters in the Beijing population.
- To investigate age- and sex-related coagulation characteristics using TEG.
- To provide a basis for accurate TEG interpretation in Beijing residents.
Main Methods:
- TEG analysis was performed on 17,708 healthy volunteers in Beijing.
- Volunteers were categorized into young/middle-aged (20-59) and elderly (≥60) groups.
- Reference ranges were calculated for reaction time (R), coagulation time (K), α-angle, and maximum thrombus consistency (MA), stratified by age and sex.
Main Results:
- Established 95% reference ranges for TEG parameters in Beijing: R (5.1-10 min), K (1.3-3.8 min), α-angle (44.9-70.2°), MA (50.4-71 min).
- Significant differences (P<0.001) were observed in TEG parameters between age groups and sexes.
- Distinct reference ranges were derived for young/middle-aged and elderly populations.
Conclusions:
- The Beijing population exhibits a tendency towards hypocoagulability compared to manufacturer standards.
- Younger individuals showed lower coagulation activity than the elderly.
- Women demonstrated higher coagulation activity than men within the same age group.
