ASPM and TROAP gene expression as potential malignant tumor markers.

Area of Science:

• Oncology
• Molecular Biology
• Bioinformatics

Background:

• Assembly factor for spindle microtubules (ASPM) and trophinin-associated protein (TROAP) are implicated in tumorigenesis.
• No comprehensive pancancer analyses of ASPM and TROAP have been conducted.

Purpose of the Study:

• To investigate the potential oncogenic functions of ASPM and TROAP across 31 cancer types.
• To explore the correlation between ASPM and TROAP expression and patient outcomes.

Main Methods:

• Utilized The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), GCBI, and GEO datasets.
• Employed various bioinformatics methods, including protein-protein interaction network (PPI) analysis.
• Analyzed expression profiles and survival data.

Main Results:

• ASPM and TROAP were highly expressed in most cancers, showing a strong positive correlation.
• Elevated ASPM and TROAP expression correlated with decreased patient life expectancy.
• Both proteins regulate cell replication in the S&G2 phase; TROAP regulates ASPM via CDC20.

Conclusions:

• ASPM and TROAP promote tumor malignancy and development by regulating cell cycle progression.
• The significant correlation and similar expression profiles suggest a cooperative role in cancer.
• ASPM and TROAP are potential biomarkers and therapeutic targets for cancer treatment.